MOCS1

Across TCGA patient cohorts, MOCS1 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MOCS1-associated genes across cancer lineages are Tuberin_pT1462, eIF4E, and ACC1. Each is linked with MOCS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MOCS1-to-partner and partner-to-MOCS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin_pT1462 grouped by MOCS1-low versus MOCS1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOCS1→partner) and Y-score (partner→MOCS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Tuberin_pT1462 →	+0.345	+3.000	.032	.036	3	2
UCEC	eIF4E →	+0.220	+2.502	.007	.002	3	2
UCEC	ACC1 →	+0.294	+2.183	.039	.033	3	2
UCEC	Notch1 →	+0.171	+2.009	.001	.017	3	2
COAD	PCNA →	+0.281	+2.820	.021	.035	3	2
UCEC	Caspase-7-cleavedD198 →	+0.631	+2.479	.006	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Tuberin_pT1462 by MOCS1 expression — SKCM

Explore this box plot interactively →