MOCS1

Across TCGA pan-cancer cohorts, MOCS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MOCS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MOCS1 RNA is repressed in tumor relative to normal tissue. In most cancer types MOCS1 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and LUAD are the cancer types where MOCS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MOCS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−1.613	<.001	12	view →
THCA	All	III,IV	−0.654	<.001	11	view →
LUAD	Female	III,IV	−1.709	<.001	9	view →
KIRP	Male	All	−0.823	<.001	9	view →
LUSC	Female	II,III,IV	−1.858	<.001	7	view →
BRCA	All	All	−1.710	<.001	6	view →
KIRC	Male	II,III,IV	−0.461	.001	5	view →
KICH	Male	All	−0.901	.001	4	view →
BLCA	Female	IV	+1.233	.025	1	view →
READ	All	II,III,IV	−1.020	.029	1	view →
STAD	All	All	−0.533	.012	1	view →
HNSC	Male	All	−0.463	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MOCS1–COAD

Open the COAD breakdown →