MOCOS

Across TCGA patient cohorts, MOCOS protein abundance is significantly associated with the RNA expression of many other genes, with 6,191 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MOCOS-associated genes across cancer lineages are GJB2, RN7SL108P, and TMEM38B. Each is linked with MOCOS in more than 2 cancer types. Because this analysis shows association rather than direction, both MOCOS-to-partner and partner-to-MOCOS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MOCOS versus GJB2 in UCEC, with a Pearson correlation of 0.26.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOCOS→partner) and Y-score (partner→MOCOS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GJB2 →	+1.498	+0.502	<.001	<.001	3	3
UCEC	RN7SL108P →	-0.682	-0.377	<.001	<.001	3	3
CCRCC	TMEM38B →	-1.187	-1.204	.001	.007	3	3
CCRCC	FRAS1 →	-1.663	-1.470	<.001	<.001	3	3
LSCC	RPL12P44 →	-0.531	-0.433	.001	<.001	3	3
HNSC	DDAH1 →	-0.741	-0.708	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,191 associations by consensus.

MOCOS vs GJB2 — UCEC

Explore this scatter interactively →