MOB3C

Across TCGA pan-cancer cohorts, MOB3C mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MOB3C data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MOB3C mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MOB3C expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and LSCC are the cancer types where MOB3C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.775	0.487	<.001	24	view →
CCRCC	DFS	Quartile	All	0.952	0.359	.010	8	view →
LSCC	DFS	Quartile	II,III,IV	0.887	0.198	.024	4	view →
LUAD	OS	Median	All	0.685	0.845	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MOB3C–HNSC (DFS)

Open the HNSC breakdown →