MOB3C

Across TCGA pan-cancer cohorts, MOB3C RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MOB3C’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MOB3C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MOB3C is over-expressed in tumor, although a few such as LUAD and KICH show the opposite, repressed pattern.

HNSC, LUAD, and KICH are the cancer types where MOB3C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MOB3C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.044	<.001	11	view →
LUAD	All	III,IV	−0.825	<.001	11	view →
KICH	Male	II,III,IV	−1.154	<.001	10	view →
KIRC	Female	All	+0.468	<.001	7	view →
UCEC	All	All	−1.283	<.001	6	view →
BRCA	All	III,IV	−0.876	<.001	6	view →
LUSC	All	II,III,IV	−0.774	<.001	6	view →
LIHC	All	II,III,IV	+0.444	.004	4	view →
CHOL	Male	All	+1.151	<.001	3	view →
PRAD	All	All	−0.563	<.001	2	view →
THCA	All	All	−0.236	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MOB3C–HNSC

Open the HNSC breakdown →