MOB3C

Across TCGA patient cohorts, MOB3C mutation is significantly associated with the RNA expression of many other genes, with 628 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MOB3C-associated genes across cancer lineages are RNVU1-2A, OR6V1, and RN7SKP44. Each is linked with MOB3C in more than 1 cancer types. Because this analysis shows association rather than direction, both MOB3C-to-partner and partner-to-MOB3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNVU1-2A grouped by MOB3C-low versus MOB3C-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOB3C→partner) and Y-score (partner→MOB3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNVU1-2A →	+0.250	+4.276	.007	.008	3	2
CESC	OR6V1 →	+0.049	+5.507	<.001	<.001	3	2
UCEC	RN7SKP44 →	+0.083	+2.551	.005	.006	3	2
COAD	RNY3P2 →	+0.871	+4.790	<.001	.006	3	1
COAD	RN7SKP87 →	+0.272	+4.354	<.001	.007	3	1
COAD	RNU6-540P →	+0.597	+4.681	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 628 associations by consensus.

RNVU1-2A by MOB3C expression — CESC

Explore this box plot interactively →