MOB3C

Across TCGA patient cohorts, MOB3C mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MOB3C-associated genes across cancer lineages are ERK2, EGFR_pY1068, and JNK2. Each is linked with MOB3C in more than 1 cancer types. Because this analysis shows association rather than direction, both MOB3C-to-partner and partner-to-MOB3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by MOB3C-low versus MOB3C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOB3C→partner) and Y-score (partner→MOB3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.180	+2.115	.032	.019	3	2
UCEC	EGFR_pY1068 →	-0.228	-2.115	.037	.019	3	1
UCEC	JNK2 →	+0.208	+3.026	.016	.018	3	1
UCEC	Akt_pT308 →	+0.548	+2.999	.046	.035	3	1
UCEC	Tuberin_pT1462 →	+0.205	+2.331	.042	.019	3	1
UCEC	Tuberin →	+0.276	+3.169	.019	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ERK2 by MOB3C expression — UCEC

Explore this box plot interactively →