MOB3C

Across TCGA cell cohorts, MOB3C mutation is significantly associated with the mutation status of many other genes, with 665 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MOB3C-associated genes across cancer lineages are C16orf70, ERCC3, and SPTLC2. Each is linked with MOB3C in more than 2 cancer types. Because this analysis shows association rather than direction, both MOB3C-to-partner and partner-to-MOB3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C16orf70 grouped by MOB3C-low versus MOB3C-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOB3C→partner) and Y-score (partner→MOB3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C16orf70 →	+4.309	+4.560	.007	.007	1	3
BLOOD_Leukemia	ERCC3 →	+4.894	+4.894	.004	.004	1	3
BLOOD_Leukemia	SPTLC2 →	+5.894	+5.321	.002	.002	1	2
BLOOD_Leukemia	TRPC4AP →	+4.894	+5.870	<.001	<.001	1	2
BLOOD_Leukemia	PTK6 →	+4.309	+4.560	.007	.007	1	2
BLOOD_Leukemia	NOP56 →	+4.894	+5.870	<.001	<.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 665 associations by consensus.

C16orf70 by MOB3C expression — BLOOD_Leukemia

Explore this box plot interactively →