MOB3B

Across TCGA pan-cancer cohorts, MOB3B mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MOB3B data layer compared with 28 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher MOB3B mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MOB3B expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

UCEC, PDAC, and LSCC are the cancer types where MOB3B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.875	1.000	.003	34	view →
PDAC	DFS	Tertile	III,IV	0.216	0.834	.024	11	view →
LSCC	OS	Quartile	III,IV	0.848	0.418	.013	8	view →
LUAD	DFS	Tertile	All	1.000	0.495	.008	7	view →
HNSC	OS	Quartile	II,III,IV	0.677	1.000	.020	4	view →
GBM	OS	Quartile	All	0.731	0.428	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MOB3B–UCEC (OS)

Open the UCEC breakdown →