MOB3B

Across TCGA pan-cancer cohorts, MOB3B mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of MOB3B’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where MOB3B mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types MOB3B is over-expressed in tumor, although a few such as LUAD and LSCC show the opposite, repressed pattern.

LUAD, LSCC, and CCRCC are the cancer types where MOB3B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MOB3B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	III,IV	−0.624	<.001	9	view →
LSCC	Male	II,III,IV	−0.608	<.001	9	view →
CCRCC	All	III,IV	+0.399	<.001	6	view →
PDAC	All	All	−0.441	<.001	5	view →
HNSC	All	III,IV	+0.256	.034	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

MOB3B–LUAD

Open the LUAD breakdown →