MOB3A

Across TCGA patient cohorts, MOB3A mutation is significantly associated with the RNA expression of many other genes, with 1,738 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MOB3A-associated genes across cancer lineages are PPP1R9A-AS1, TRBV21-1, and MIR3661. Each is linked with MOB3A in more than 1 cancer types. Because this analysis shows association rather than direction, both MOB3A-to-partner and partner-to-MOB3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP1R9A-AS1 grouped by MOB3A-low versus MOB3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOB3A→partner) and Y-score (partner→MOB3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPP1R9A-AS1 →	+0.186	+2.342	.002	.004	3	2
UCEC	TRBV21-1 →	+0.274	+2.091	.004	.003	3	2
UCEC	MIR3661 →	+0.689	+2.479	<.001	<.001	3	2
SKCM	RPS24P1 →	+0.535	+4.385	<.001	.008	3	1
SKCM	RN7SL104P →	+0.129	+4.385	<.001	.008	3	1
UCEC	OR6R2P →	+0.241	+2.061	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,738 associations by consensus.

PPP1R9A-AS1 by MOB3A expression — UCEC

Explore this box plot interactively →