MOB2

Across TCGA pan-cancer cohorts, MOB2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MOB2 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher MOB2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MOB2 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC, HNSC, and LUAD are the cancer types where MOB2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	II,III,IV	0.675	0.325	<.001	15	view →
HNSC	DFS	Tertile	All	0.787	0.543	.008	11	view →
LUAD	DFS	Quartile	III,IV	0.240	0.953	.006	9	view →
UCEC	DFS	Quartile	III,IV	0.643	1.000	.043	4	view →
CCRCC	DFS	Quartile	All	1.000	0.614	.047	3	view →
GBM	OS	Tertile	All	0.422	0.578	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MOB2–PDAC (OS)

Open the PDAC breakdown →