MOB2

Across TCGA pan-cancer cohorts, MOB2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MOB2’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where MOB2 RNA is repressed in tumor relative to normal tissue. In most cancer types MOB2 is over-expressed in tumor, although a few such as BLCA and LUAD show the opposite, repressed pattern.

BLCA, LIHC, and LUAD are the cancer types where MOB2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MOB2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	−0.974	<.001	11	view →
LIHC	Female	II,III,IV	+1.112	<.001	9	view →
LUAD	Male	All	−0.599	<.001	9	view →
UCEC	All	All	−0.960	<.001	6	view →
KIRC	All	All	+0.290	<.001	6	view →
CHOL	All	All	+1.659	<.001	5	view →
READ	All	All	−0.895	<.001	5	view →
BRCA	All	II,III,IV	−0.347	<.001	4	view →
COAD	All	II,III,IV	−0.289	.012	4	view →
LUSC	All	All	−0.220	.010	3	view →
PRAD	All	All	−0.390	<.001	2	view →
THCA	All	All	+0.146	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MOB2–BLCA

Open the BLCA breakdown →