MOB2

Across TCGA patient cohorts, MOB2 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MOB2-associated genes across cancer lineages are ER-alpha, p62 Lck ligand, and SLC1A5. Each is linked with MOB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MOB2-to-partner and partner-to-MOB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha grouped by MOB2-low versus MOB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOB2→partner) and Y-score (partner→MOB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ER-alpha →	+1.018	+3.000	.023	.036	3	1
UCEC	p62 Lck ligand →	+0.491	+3.009	.005	.019	3	1
UCEC	SLC1A5 →	-0.575	-2.992	.019	.036	3	1
UCEC	STAT3_pY705 →	-0.413	-3.169	.004	.020	3	1
UCEC	YB-1 →	-0.204	-3.143	.019	.020	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ER-alpha by MOB2 expression — UCEC

Explore this box plot interactively →