MOB1B

Across TCGA patient cohorts, MOB1B mutation is significantly associated with the immune_cell of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MOB1B-associated genes across cancer lineages are CD8+ naive T-cells, Class-switched memory B-cells, and lymphatic Endothelial cells. Each is linked with MOB1B in more than 1 cancer types. Because this analysis shows association rather than direction, both MOB1B-to-partner and partner-to-MOB1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ naive T-cells grouped by MOB1B-low versus MOB1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOB1B→partner) and Y-score (partner→MOB1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD8+ naive T-cells →	+0.022	+1.720	.028	.013	3	1
UCEC	Class-switched memory B-cells →	-0.046	-2.629	.036	.004	3	1
UCEC	lymphatic Endothelial cells →	-0.020	-2.033	.026	.006	3	1
UCEC	Macrophages M1 →	+0.013	+2.153	.019	.013	3	1
UCEC	Macrophages M2 →	+0.009	+1.439	.022	.042	3	1
UCEC	MEP →	+0.023	+3.254	.032	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

CD8+ naive T-cells by MOB1B expression — UCEC

Explore this box plot interactively →