MOB1B

Across TCGA pan-cancer cohorts, MOB1B RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MOB1B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MOB1B RNA is repressed in tumor relative to normal tissue. In most cancer types MOB1B is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, HNSC, and THCA are the cancer types where MOB1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MOB1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.399	<.001	10	view →
HNSC	All	All	+0.386	<.001	9	view →
THCA	All	II,III,IV	−0.556	<.001	8	view →
KIRP	Male	All	−1.064	<.001	6	view →
CHOL	Female	All	+1.833	<.001	5	view →
LIHC	All	II,III,IV	+0.610	<.001	5	view →
KICH	All	All	+0.618	.003	3	view →
LUAD	Female	II,III,IV	−0.407	.012	3	view →
LUSC	All	All	−0.396	<.001	3	view →
BRCA	All	IV	+0.615	.040	2	view →
PRAD	All	All	+0.407	<.001	2	view →
STAD	All	II,III,IV	+0.608	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MOB1B–KIRC

Open the KIRC breakdown →