MOB1B

Across TCGA cell cohorts, MOB1B mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MOB1B-associated genes across cancer lineages are SEMG2, TAAR5, and TBC1D21. Each is linked with MOB1B in more than 1 cancer types. Because this analysis shows association rather than direction, both MOB1B-to-partner and partner-to-MOB1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEMG2 grouped by MOB1B-low versus MOB1B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOB1B→partner) and Y-score (partner→MOB1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SEMG2 →	+0.420	+2.878	.003	.009	3	1
LARGE_INTESTINE	TAAR5 →	+0.010	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	C12orf40 →	+0.007	+3.514	<.001	.001	3	1
LARGE_INTESTINE	BPY2 →	+0.012	+3.700	<.001	.009	3	1
LARGE_INTESTINE	BPY2B →	+0.012	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

SEMG2 by MOB1B expression — LARGE_INTESTINE

Explore this box plot interactively →