MNDA

Across TCGA patient cohorts, MNDA mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MNDA-associated genes across cancer lineages are Ku80, p70-S6K_pT389, and ATM. Each is linked with MNDA in more than 1 cancer types. Because this analysis shows association rather than direction, both MNDA-to-partner and partner-to-MNDA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by MNDA-low versus MNDA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MNDA→partner) and Y-score (partner→MNDA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.179	+1.335	.023	.019	3	2
UCEC	p70-S6K_pT389 →	-0.226	-2.312	<.001	<.001	3	2
UCEC	ATM →	-0.466	-2.687	.002	.005	3	2
UCEC	BRCA2 →	-0.093	-1.433	.035	.023	3	2
UCEC	BRD4 →	+0.206	+1.999	.026	.028	3	2
UCEC	Cyclin-B1 →	+0.452	+2.321	.016	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Ku80 by MNDA expression — UCEC

Explore this box plot interactively →