MN1

Across TCGA cell cohorts, MN1 mutation is significantly associated with the mutation status of many other genes, with 5,425 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MN1-associated genes across cancer lineages are PPFIA3, TOP3A, and TMEM131. Each is linked with MN1 in more than 5 cancer types. Because this analysis shows association rather than direction, both MN1-to-partner and partner-to-MN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPFIA3 grouped by MN1-low versus MN1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MN1→partner) and Y-score (partner→MN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PPFIA3 →	+3.115	+3.440	.003	.003	1	6
LARGE_INTESTINE	TOP3A →	+3.278	+2.491	<.001	<.001	1	6
BREAST	TMEM131 →	+3.222	+3.222	.009	.009	1	5
STOMACH	SMARCA2 →	+3.700	+3.700	.001	.001	1	5
CNS	NLRP6 →	+5.000	+4.044	.008	.008	1	5
BLOOD_Leukemia	DLGAP2 →	+2.232	+2.282	.006	.006	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,425 associations by consensus.

PPFIA3 by MN1 expression — STOMACH

Explore this box plot interactively →