MMUT

Across TCGA patient cohorts, MMUT mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMUT-associated genes across cancer lineages are eEF2, JNK_pT183_Y185, and mTOR_pS2448. Each is linked with MMUT in more than 2 cancer types. Because this analysis shows association rather than direction, both MMUT-to-partner and partner-to-MMUT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by MMUT-low versus MMUT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMUT→partner) and Y-score (partner→MMUT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.271	+2.459	.039	.018	3	3
UCEC	JNK_pT183_Y185 →	-0.171	-2.115	.005	.017	3	3
UCEC	mTOR_pS2448 →	-0.110	-1.680	.043	.042	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.415	-1.834	.012	.008	3	2
UCEC	PCNA →	+0.246	+1.847	.001	.008	3	2
UCEC	ATM →	-0.698	-2.247	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

eEF2 by MMUT expression — UCEC

Explore this box plot interactively →