MMUT

Across TCGA cell cohorts, MMUT mutation is significantly associated with the RNA expression of many other genes, with 85 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MMUT-associated genes across cancer lineages are CHRNA2, KLHL40, and ALPI. Each is linked with MMUT in more than 1 cancer types. Because this analysis shows association rather than direction, both MMUT-to-partner and partner-to-MMUT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHRNA2 grouped by MMUT-low versus MMUT-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMUT→partner) and Y-score (partner→MMUT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CHRNA2 →	+0.052	+3.684	<.001	.006	3	1
SKIN	KLHL40 →	+0.007	+4.688	<.001	<.001	3	1
SKIN	ALPI →	+0.010	+4.347	<.001	.001	3	1
SKIN	OR2B2 →	+0.021	+3.684	<.001	.006	3	1
SKIN	SPAG11A →	+0.044	+4.437	<.001	.004	3	1
BREAST	NKX2-4 →	+0.110	+3.672	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 85 associations by consensus.

CHRNA2 by MMUT expression — SKIN

Explore this box plot interactively →