MMS19

Across TCGA patient cohorts, MMS19 protein abundance is significantly associated with the RNA expression of many other genes, with 11,114 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible MMS19-associated genes across cancer lineages are GLRX3, NPM3, and HLF. Each is linked with MMS19 in more than 6 cancer types. Because this analysis shows association rather than direction, both MMS19-to-partner and partner-to-MMS19 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MMS19 versus GLRX3 in BRCA, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMS19→partner) and Y-score (partner→MMS19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GLRX3 →	+0.441	+0.285	<.001	<.001	3	7
LSCC	NPM3 →	+0.787	+0.288	<.001	<.001	3	6
LUAD	HLF →	-1.061	-0.168	<.001	.001	3	6
LUAD	HMGA1 →	+1.239	+0.294	<.001	<.001	3	5
LSCC	DPCD →	+0.554	+0.209	<.001	<.001	3	5
UCEC	SGPL1 →	+0.479	+0.195	.009	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,114 associations by consensus.

MMS19 vs GLRX3 — BRCA

Explore this scatter interactively →