MMS19

Across TCGA cell cohorts, MMS19 mutation is significantly associated with the mutation status of many other genes, with 6,572 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MMS19-associated genes across cancer lineages are SIRT7, RFX5, and MAGI1. Each is linked with MMS19 in more than 4 cancer types. Because this analysis shows association rather than direction, both MMS19-to-partner and partner-to-MMS19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIRT7 grouped by MMS19-low versus MMS19-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMS19→partner) and Y-score (partner→MMS19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SIRT7 →	+5.415	+5.415	.004	.004	1	5
OVARY	RFX5 →	+5.415	+5.415	.004	.004	1	5
BLOOD_Leukemia	MAGI1 →	+2.499	+2.697	.002	.002	1	5
STOMACH	AXIN2 →	+4.807	+4.807	.008	.008	1	4
STOMACH	AATK →	+4.807	+4.807	.008	.008	1	4
STOMACH	PCDHGA4 →	+4.807	+4.807	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,572 associations by consensus.

SIRT7 by MMS19 expression — OVARY

Explore this box plot interactively →