MMRN1

Across TCGA patient cohorts, MMRN1 mutation is significantly associated with the RNA expression of many other genes, with 3,346 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible MMRN1-associated genes across cancer lineages are GLRX5, DLGAP5, and PRC1. Each is linked with MMRN1 in more than 4 cancer types. Because this analysis shows association rather than direction, both MMRN1-to-partner and partner-to-MMRN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GLRX5 grouped by MMRN1-low versus MMRN1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMRN1→partner) and Y-score (partner→MMRN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GLRX5 →	+0.355	+1.810	.002	.008	3	5
LUAD	DLGAP5 →	+0.703	+2.689	.001	<.001	3	5
LUAD	PRC1 →	+0.654	+2.461	<.001	.001	3	5
UCEC	PKN3 →	+0.431	+1.695	.003	.005	3	4
LUAD	TYMSOS →	+0.493	+2.620	<.001	.005	3	4
UCEC	TIMM22 →	+0.310	+1.960	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,346 associations by consensus.

GLRX5 by MMRN1 expression — SKCM

Explore this box plot interactively →