MMP9

Across TCGA pan-cancer cohorts, MMP9 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MMP9 data layer compared with 29 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MMP9 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MMP9 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

LUAD, CCRCC, and UCEC are the cancer types where MMP9 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.327	0.811	<.001	19	view →
CCRCC	OS	Median	IV	0.785	0.123	.009	17	view →
UCEC	OS	Median	II,III,IV	1.000	0.620	.011	8	view →
PDAC	DFS	Tertile	All	0.704	0.813	.036	6	view →
OV	DFS	Median	All	1.000	0.874	.045	4	view →
LSCC	DFS	Median	All	0.828	0.498	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MMP9–LUAD (OS)

Open the LUAD breakdown →