MMP9

Across TCGA pan-cancer cohorts, MMP9 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of MMP9’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MMP9 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MMP9 is over-expressed in tumor.

HNSC, KIRC, and COAD are the cancer types where MMP9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MMP9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+5.450	<.001	12	view →
KIRC	All	IV	+2.928	<.001	12	view →
COAD	All	III,IV	+2.260	<.001	10	view →
LUAD	All	III,IV	+3.214	<.001	9	view →
THCA	All	III,IV	+2.720	<.001	9	view →
LUSC	Male	All	+2.989	<.001	8	view →
BLCA	All	All	+1.986	.002	8	view →
LIHC	All	II,III,IV	+1.810	<.001	8	view →
STAD	Female	All	+3.308	<.001	7	view →
UCEC	All	All	+2.617	<.001	6	view →
BRCA	All	III,IV	+2.590	<.001	6	view →
KIRP	All	All	+1.478	.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

MMP9–HNSC

Open the HNSC breakdown →