MMP9

Across TCGA patient cohorts, MMP9 protein abundance is significantly associated with the RNA expression of many other genes, with 19,165 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MMP9-associated genes across cancer lineages are ADGRE3, BCL2A1, and CXCL3. Each is linked with MMP9 in more than 9 cancer types. Because this analysis shows association rather than direction, both MMP9-to-partner and partner-to-MMP9 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MMP9 versus ADGRE3 in LSCC, with a Pearson correlation of 0.71.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP9→partner) and Y-score (partner→MMP9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ADGRE3 →	+0.825	+1.236	<.001	<.001	3	10
CCRCC	BCL2A1 →	+1.304	+0.912	<.001	<.001	3	10
UCEC	CXCL3 →	+1.652	+1.168	<.001	<.001	3	10
LSCC	CXCL1 →	+2.139	+1.076	<.001	<.001	3	10
UCEC	CLEC4D →	+0.600	+0.773	<.001	.001	3	10
LUAD	CXCL8 →	+2.441	+1.101	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,165 associations by consensus.

MMP9 vs ADGRE3 — LSCC

Explore this scatter interactively →