MMP9

Across TCGA cell cohorts, MMP9 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,116 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MMP9-associated GO terms across cancer lineages are Regulation of entry of bacterium into host cell, Negative regulation of epithelial cell differentiation involved in kidney development, and Positive regulation of extracellular matrix organization. Each is linked with MMP9 in more than 8 cancer types. Because this analysis shows association rather than direction, both MMP9-to-partner and partner-to-MMP9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of entry of bacterium into host cell grouped by MMP9-low versus MMP9-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP9→partner) and Y-score (partner→MMP9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Regulation of entry of bacterium into host cell →	+0.120	+0.297	<.001	.005	3	9
URINARY_TRACT	Negative regulation of epithelial cell differentiation involved in kidney development →	-0.279	-1.382	<.001	<.001	3	8
SKIN	Positive regulation of extracellular matrix organization →	+0.130	+0.447	<.001	.003	3	8
SKIN	Regulation of extrinsic apoptotic signaling pathway →	+0.045	+0.369	.004	.004	2	9
PANCREAS	Plasminogen activation →	+0.315	+1.563	.001	.007	3	7
SKIN	Regulation of fibrinolysis →	+0.270	+0.309	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,116 associations by consensus.

Regulation of entry of bacterium into host cell by MMP9 expression — SKIN

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