MMP9

Across TCGA cell cohorts, MMP9 mutation is significantly associated with the RNA expression of many other genes, with 195 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MMP9-associated genes across cancer lineages are PRSS58, GPR101, and SERPINA10. Each is linked with MMP9 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMP9-to-partner and partner-to-MMP9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS58 grouped by MMP9-low versus MMP9-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP9→partner) and Y-score (partner→MMP9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PRSS58 →	+0.117	+4.930	.003	.008	3	1
URINARY_TRACT	GPR101 →	+0.020	+5.087	<.001	.004	3	1
BLOOD_Leukemia	SERPINA10 →	+0.083	+3.912	.002	.006	3	1
BLOOD_Leukemia	LRIT1 →	+0.032	+4.269	<.001	.002	3	1
BLOOD_Leukemia	C16orf92 →	+0.175	+4.037	<.001	.004	3	1
BLOOD_Leukemia	PRR30 →	+0.021	+4.269	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 195 associations by consensus.

PRSS58 by MMP9 expression — SOFT_TISSUE

Explore this box plot interactively →