MMP8

Across TCGA pan-cancer cohorts, MMP8 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MMP8 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MMP8 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MMP8 expression acts as an unfavorable survival marker, although some lineages such as OV and LSCC show a favorable association.

LUAD, PDAC, and OV are the cancer types where MMP8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.322	0.824	.002	29	view →
PDAC	DFS	Quartile	II,III,IV	0.344	0.696	.008	13	view →
OV	DFS	Median	All	1.000	0.840	.048	4	view →
CCRCC	OS	Quartile	III,IV	0.754	1.000	.026	3	view →
LSCC	DFS	Median	All	0.828	0.498	.042	2	view →
UCEC	DFS	Median	All	1.000	0.936	.021	2	view →
HNSC	DFS	Median	III,IV	0.939	1.000	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MMP8–LUAD (OS)

Open the LUAD breakdown →