Across TCGA patient cohorts, MMP17 mutation is significantly associated with the RNA expression of many other genes, with 2,677 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMP17-associated genes across cancer lineages are SMC5, MFSD14B, and RNU6-952P. Each is linked with MMP17 in more than 2 cancer types. Because this analysis shows association rather than direction, both MMP17-to-partner and partner-to-MMP17 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP17→partner) and Y-score (partner→MMP17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SMC5 →	+0.542	+3.459	<.001	.005	3	3
SKCM	MFSD14B →	+0.645	+3.516	.003	.002	3	3
CESC	RNU6-952P →	+0.409	+5.306	<.001	.006	3	2
UCEC	FGD6 →	+0.555	+2.081	<.001	.001	3	2
UCEC	POLR2A →	+0.633	+3.087	.001	<.001	3	2
UCEC	IFITM1 →	-0.947	-2.398	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,677 associations by consensus.

Exploration

MMP17 survival (RNA) · tumor vs normal (RNA) · all MMP17 data types