Across TCGA cell cohorts, MMP17 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MMP17-associated genes across cancer lineages are CT45A6, OR4D6, and KCNK18. Each is linked with MMP17 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMP17-to-partner and partner-to-MMP17 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP17→partner) and Y-score (partner→MMP17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CT45A6 →	+0.045	+4.357	<.001	.006	3	1
BLOOD_Lymphoma	OR4D6 →	+0.018	+5.209	.002	.005	3	1
BLOOD_Lymphoma	KCNK18 →	+0.019	+5.209	<.001	.005	3	1
SKIN	OR1L3 →	+0.029	+5.415	<.001	.004	3	1
SKIN	UCN3 →	+0.055	+4.977	<.001	.007	3	1
SKIN	FAM47C →	+0.006	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

MMP17 survival (RNA) · tumor vs normal (RNA) · all MMP17 data types