MMP16

Across TCGA cell cohorts, MMP16 mutation is significantly associated with the RNA expression of many other genes, with 1,004 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MMP16-associated genes across cancer lineages are DEPDC1, CAPZA1, and NFYB. Each is linked with MMP16 in more than 2 cancer types. Because this analysis shows association rather than direction, both MMP16-to-partner and partner-to-MMP16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEPDC1 grouped by MMP16-low versus MMP16-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP16→partner) and Y-score (partner→MMP16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEPDC1 →	+0.805	+3.301	.001	.003	3	3
SKIN	CAPZA1 →	+0.605	+3.212	.001	.006	3	2
SKIN	NFYB →	+0.519	+3.385	.003	.004	3	2
SKIN	PPIL4 →	+0.651	+3.237	<.001	.003	3	2
SKIN	TMTC3 →	+0.885	+3.082	<.001	.007	3	2
SKIN	OR5C1 →	+0.038	+2.754	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,004 associations by consensus.

DEPDC1 by MMP16 expression — LARGE_INTESTINE

Explore this box plot interactively →