MMP14

Across TCGA patient cohorts, MMP14 protein abundance is significantly associated with the RNA expression of many other genes, with 17,318 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MMP14-associated genes across cancer lineages are COL1A1, LOXL2, and ADAM12. Each is linked with MMP14 in more than 9 cancer types. Because this analysis shows association rather than direction, both MMP14-to-partner and partner-to-MMP14 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MMP14 versus COL1A1 in OV, with a Pearson correlation of 0.68.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP14→partner) and Y-score (partner→MMP14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	COL1A1 →	+2.633	+0.605	<.001	<.001	3	10
OV	LOXL2 →	+1.371	+0.630	<.001	<.001	3	10
OV	ADAM12 →	+2.033	+0.704	<.001	<.001	3	10
OV	MFAP2 →	+1.796	+0.527	<.001	<.001	3	9
OV	RUNX2 →	+1.373	+0.553	<.001	<.001	3	9
OV	CD276 →	+0.954	+0.563	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,318 associations by consensus.

MMP14 vs COL1A1 — OV

Explore this scatter interactively →