MMP14

Across TCGA patient cohorts, MMP14 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMP14-associated genes across cancer lineages are C-Raf, HER3_pY1289, and MEK1. Each is linked with MMP14 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMP14-to-partner and partner-to-MMP14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by MMP14-low versus MMP14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP14→partner) and Y-score (partner→MMP14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.116	+1.700	.024	.042	3	2
UCEC	HER3_pY1289 →	+0.080	+2.720	.010	.003	2	2
UCEC	MEK1 →	+0.332	+3.000	.011	<.001	3	1
UCEC	Notch1 →	+0.158	+1.584	.001	.019	3	1
UCEC	p62 Lck ligand →	+0.431	+2.916	<.001	<.001	3	1
UCEC	Rab25 →	-0.237	-3.321	.047	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

C-Raf by MMP14 expression — UCEC

Explore this box plot interactively →