MMP14

Across TCGA cell cohorts, MMP14 mutation is significantly associated with the RNA expression of many other genes, with 731 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MMP14-associated genes across cancer lineages are CSN2, EIF3L, and CCDC134. Each is linked with MMP14 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMP14-to-partner and partner-to-MMP14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CSN2 grouped by MMP14-low versus MMP14-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP14→partner) and Y-score (partner→MMP14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CSN2 →	+0.122	+5.415	<.001	.004	3	1
LARGE_INTESTINE	EIF3L →	+0.630	+3.257	<.001	.002	3	1
LARGE_INTESTINE	CCDC134 →	+0.772	+3.131	<.001	.008	3	1
LARGE_INTESTINE	SEPTIN3 →	+0.967	+2.588	.009	.004	3	1
LARGE_INTESTINE	HMGXB4 →	+0.480	+2.502	.009	.005	3	1
LARGE_INTESTINE	RPL3 →	+0.577	+3.389	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 731 associations by consensus.

CSN2 by MMP14 expression — SKIN

Explore this box plot interactively →