MMP11

Across TCGA pan-cancer cohorts, MMP11 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MMP11 data layer compared with 25 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in testicular germ cell tumors (TGCT), where higher MMP11 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MMP11 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

TGCT, READ, and LUAD are the cancer types where MMP11 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
TGCT	OS	Median	III,IV	0.003	1.000	<.001	36	view →
READ	OS	Median	II,III,IV	0.054	0.934	<.001	24	view →
LUAD	OS	Median	All	0.163	0.835	<.001	24	view →
LUSC	DFS	Median	All	0.139	0.707	.022	9	view →
LIHC	DFS	Median	All	0.100	0.543	.038	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SKCM	DFS	Median	All	1.000	0.212	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MMP11–TGCT (OS)

Open the TGCT breakdown →