MMP11

Across TCGA pan-cancer cohorts, MMP11 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of MMP11’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where MMP11 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MMP11 is over-expressed in tumor.

BLCA, HNSC, and KIRC are the cancer types where MMP11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MMP11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	+5.399	<.001	12	view →
HNSC	Female	IV	+4.591	<.001	12	view →
KIRC	Male	IV	+1.690	<.001	12	view →
COAD	Male	III,IV	+4.328	<.001	11	view →
THCA	All	III,IV	+1.959	<.001	10	view →
LUAD	Female	II,III,IV	+4.944	<.001	9	view →
LIHC	Female	II,III,IV	+3.064	<.001	9	view →
KIRP	Male	II,III,IV	+1.986	<.001	9	view →
LUSC	Female	II,III,IV	+4.624	<.001	8	view →
STAD	Male	III,IV	+4.145	<.001	8	view →
READ	All	II,III,IV	+3.357	<.001	7	view →
BRCA	All	III,IV	+5.620	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

MMP11–BLCA

Open the BLCA breakdown →