MMP11

Across TCGA pan-cancer cohorts, MMP11 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MMP11 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MMP11 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MMP11 expression acts as an unfavorable survival marker.

LUAD, PDAC, and LSCC are the cancer types where MMP11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.405	0.931	.002	15	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	12	view →
LSCC	OS	Median	All	0.727	0.912	.004	8	view →
HNSC	OS	Tertile	II,III,IV	0.815	0.942	.021	7	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MMP11–LUAD (DFS)

Open the LUAD breakdown →