MMP11

Across TCGA patient cohorts, MMP11 mutation is significantly associated with the RNA expression of many other genes, with 1,335 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMP11-associated genes across cancer lineages are TRAJ57, TRAJ11, and SNORA77. Each is linked with MMP11 in more than 2 cancer types. Because this analysis shows association rather than direction, both MMP11-to-partner and partner-to-MMP11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ57 grouped by MMP11-low versus MMP11-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP11→partner) and Y-score (partner→MMP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TRAJ57 →	+0.452	+3.220	.002	.009	3	3
COAD	TRAJ11 →	+0.562	+2.958	.005	.007	3	2
COAD	SNORA77 →	+1.056	+3.675	<.001	.004	3	2
STAD	LINC02620 →	+0.325	+3.930	<.001	.004	3	2
COAD	BPY2DP →	+0.105	+4.824	<.001	.002	3	2
COAD	TRBV10-2 →	+0.691	+3.766	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,335 associations by consensus.

TRAJ57 by MMP11 expression — COAD

Explore this box plot interactively →