MMP11

Across TCGA patient cohorts, MMP11 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMP11-associated genes across cancer lineages are eIF4G, MEK1, and MSH6. Each is linked with MMP11 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMP11-to-partner and partner-to-MMP11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by MMP11-low versus MMP11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP11→partner) and Y-score (partner→MMP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.291	+3.000	.037	.036	3	1
UCEC	MEK1 →	+0.352	+3.321	.032	.010	3	1
UCEC	MSH6 →	-0.410	-3.169	.005	.018	3	1
UCEC	p62 Lck ligand →	+0.290	+3.009	.048	.019	3	1
UCEC	P-Cadherin →	-0.142	-2.999	.028	.035	3	1
UCEC	Bak →	+0.241	+2.999	.033	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

eIF4G by MMP11 expression — UCEC

Explore this box plot interactively →