MMP11

Across TCGA cell cohorts, MMP11 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MMP11-associated genes across cancer lineages are GFRA4, MAGEB4, and STRA8. Each is linked with MMP11 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMP11-to-partner and partner-to-MMP11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRA4 grouped by MMP11-low versus MMP11-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP11→partner) and Y-score (partner→MMP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GFRA4 →	+0.022	+5.169	<.001	.005	3	1
LARGE_INTESTINE	MAGEB4 →	+0.022	+4.415	<.001	.007	3	1
LARGE_INTESTINE	STRA8 →	+0.161	+4.415	<.001	.007	3	1
LARGE_INTESTINE	ZNF804B →	+0.016	+4.415	<.001	.007	3	1
LARGE_INTESTINE	BPY2 →	+0.022	+5.022	<.001	.002	3	1
LARGE_INTESTINE	BPY2B →	+0.022	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

GFRA4 by MMP11 expression — BREAST

Explore this box plot interactively →