MMP10

Across TCGA patient cohorts, MMP10 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMP10-associated genes across cancer lineages are Akt_pT308, GSK-3a-b_pS21_S9, and MEK1. Each is linked with MMP10 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMP10-to-partner and partner-to-MMP10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pT308 grouped by MMP10-low versus MMP10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP10→partner) and Y-score (partner→MMP10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pT308 →	+0.653	+3.321	.011	.009	3	2
UCEC	GSK-3a-b_pS21_S9 →	+0.448	+1.594	.011	.042	3	1
UCEC	MEK1 →	+0.382	+3.000	.011	.001	3	1
UCEC	MSH2 →	-0.300	-2.433	.001	.018	3	1
UCEC	MSH6 →	-0.352	-2.321	.009	.033	3	1
UCEC	Notch1 →	+0.141	+2.183	.015	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Akt_pT308 by MMP10 expression — UCEC

Explore this box plot interactively →