MMP10

Across TCGA pan-cancer cohorts, MMP10 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MMP10’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MMP10 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MMP10 is over-expressed in tumor.

HNSC, COAD, and LUAD are the cancer types where MMP10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MMP10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+4.357	<.001	12	view →
COAD	Female	II,III,IV	+2.328	<.001	11	view →
LUAD	Female	II,III,IV	+2.266	<.001	9	view →
THCA	All	All	+0.402	<.001	7	view →
LUSC	Female	All	+4.537	<.001	6	view →
UCEC	All	II,III,IV	+2.326	<.001	6	view →
BRCA	All	III,IV	+2.022	<.001	6	view →
STAD	All	All	+1.532	<.001	6	view →
LIHC	All	All	+0.409	.004	5	view →
CHOL	All	All	+2.020	<.001	4	view →
ESCA	All	All	+3.985	<.001	3	view →
READ	All	All	+2.688	.003	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MMP10–HNSC

Open the HNSC breakdown →