MMP10

Across TCGA cell cohorts, MMP10 mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MMP10-associated genes across cancer lineages are RETN, CLEC4M, and C5orf52. Each is linked with MMP10 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMP10-to-partner and partner-to-MMP10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RETN grouped by MMP10-low versus MMP10-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP10→partner) and Y-score (partner→MMP10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RETN →	+0.125	+4.523	<.001	.003	3	1
LUNG_SCLC	CLEC4M →	+0.081	+4.523	<.001	.003	3	1
LUNG_SCLC	C5orf52 →	+0.052	+4.643	<.001	.004	3	1
CNS	C4orf51 →	+0.164	+4.981	.004	.008	3	1
LUNG_NSCLC_LUAD	GALR1 →	+0.026	+4.266	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR5J2 →	+0.066	+4.266	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

RETN by MMP10 expression — LUNG_SCLC

Explore this box plot interactively →