Across TCGA patient cohorts, MMP1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMP1-associated genes across cancer lineages are Notch1, PDCD4, and TFRC. Each is linked with MMP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MMP1-to-partner and partner-to-MMP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP1→partner) and Y-score (partner→MMP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.163	+3.179	.016	.010	3	2
UCEC	PDCD4 →	-0.671	-3.449	.003	.005	2	3
SKCM	TFRC →	+0.719	+3.321	.013	.010	2	2
UCEC	FASN →	+0.444	+2.459	.019	.020	3	1
UCEC	MEK1 →	+0.460	+3.321	.009	.010	3	1
UCEC	MIG-6 →	+0.111	+3.179	.020	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

MMP1 survival (RNA) · tumor vs normal (RNA) · all MMP1 data types