MMGT1

Across TCGA patient cohorts, MMGT1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMGT1-associated genes across cancer lineages are 14-3-3_beta, eEF2, and Acetyl-a-Tubulin-Lys40. Each is linked with MMGT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMGT1-to-partner and partner-to-MMGT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by MMGT1-low versus MMGT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMGT1→partner) and Y-score (partner→MMGT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.087	-2.432	.016	.018	3	1
UCEC	eEF2 →	+0.309	+2.459	.016	.019	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.445	+1.584	.015	.019	3	1
UCEC	INPP4B →	-0.297	-2.115	.010	.017	3	1
UCEC	JNK_pT183_Y185 →	-0.171	-2.115	.004	.017	3	1
UCEC	MSH2 →	-0.179	-1.973	.031	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

14-3-3_beta by MMGT1 expression — UCEC

Explore this box plot interactively →