MMGT1

Across TCGA pan-cancer cohorts, MMGT1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MMGT1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MMGT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MMGT1 is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.

HNSC, LIHC, and BLCA are the cancer types where MMGT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MMGT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.821	<.001	12	view →
LIHC	Male	II,III,IV	+1.094	<.001	9	view →
BLCA	Male	All	−0.612	.003	7	view →
THCA	Female	All	−0.574	<.001	6	view →
BRCA	Female	All	−0.339	<.001	6	view →
CHOL	Female	All	+2.176	<.001	5	view →
UCEC	All	All	−1.111	<.001	2	view →
STAD	Male	II,III,IV	+0.698	.036	2	view →
LUSC	Female	II,III,IV	−0.641	.008	2	view →
KIRP	Female	II,III,IV	+0.639	.018	2	view →
PRAD	All	All	−0.268	.046	2	view →
LUAD	Female	III,IV	−0.419	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MMGT1–HNSC

Open the HNSC breakdown →