MME-AS1

Across TCGA pan-cancer cohorts, MME-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated MME-AS1 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher MME-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MME-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LIHC show a favorable association.

KICH, SKCM, and HNSC are the cancer types where MME-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	All	0.559	0.966	<.001	108	view →
SKCM	DFS	Tertile	II,III,IV	0.159	0.315	<.001	44	view →
HNSC	OS	Tertile	II,III,IV	0.678	0.758	.015	42	view →
UCEC	DFS	Tertile	III,IV	0.639	0.805	.026	36	view →
MESO	OS	Tertile	All	0.258	0.426	.014	27	view →
CESC	DFS	Tertile	IV	0.267	0.566	.047	18	view →
KIRC	DFS	Quartile	IV	0.686	0.378	.031	14	view →
LUSC	DFS	Quartile	II,III,IV	0.515	0.814	.008	14	view →
KIRP	DFS	Tertile	All	0.427	0.655	.015	12	view →
LIHC	DFS	Quartile	III,IV	0.386	0.110	.027	11	view →
LGG	DFS	Tertile	All	0.851	0.719	.024	9	view →
PCPG	DFS	Tertile	All	0.536	0.872	.012	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

MME-AS1–KICH (DFS)

Open the KICH breakdown →