MME-AS1

Across TCGA pan-cancer cohorts, MME-AS1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of MME-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where MME-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types MME-AS1 is over-expressed in tumor, although a few such as KIRP and BRCA show the opposite, repressed pattern.

KIRP, BRCA, and LUAD are the cancer types where MME-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MME-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	−0.249	<.001	9	view →
BRCA	All	III,IV	−0.618	<.001	6	view →
LUAD	Female	All	−0.139	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

MME-AS1–KIRP

Open the KIRP breakdown →